About the role
PsiThera is seeking a talented and creative medicinal chemist with strong hands-on experience advancing discovery programs from hit identification through development candidate nomination. This candidate will bring deep expertise in synthetic and medicinal chemistry, with a demonstrated track record optimizing peptide therapeutics for oral delivery, particularly macrocyclic peptides. The role requires practical experience designing and synthesizing complex molecules, peptides and peptidomimetics; applying structure-activity relationship principles to improve potency, selectivity, stability, permeability, and ADME/PK properties; and using multiparameter optimization to balance efficacy, developability, and oral exposure. The candidate must be able to integrate computational modeling, structural information, biophysical data, and biological assay results into clear design hypotheses and translate those hypotheses into executable chemistry plans. Appointable candidates will also have experience directing chemistry CRO, leading teams and communicating decisions clearly to cross-functional teams to progress programs efficiently toward development candidates.
PsiThera is creating better therapeutics through an integrated molecular design paradigm that leverages best-in-class physics-based and AI technologies honed through decades of research and innovation. Our focus is first-in-class inflammation and immunology (I&I) small molecule therapeutics. We have assembled a diverse team with extensive experience across disciplines ranging from physics and computer science to chemistry, biology, biochemistry, and structural biology. This continuum of complementary skills drives our scientific vision to deliver meaningful therapeutics to patients in need. We are patient-inspired, perseverant, synergistic, supportive, intrepid, and inclusive. If you’re passionate about advancing medicine in a fast-paced, innovative environment, and eager to contribute to a team that blends advanced computation with drug discovery, PsiThera might be the perfect fit for you.
At PsiThera, we are a lean, high-performing team dedicated to pushing boundaries and achieving growth—both personally and scientifically. We seek individuals who are smart, collaborative, and thrive in a dynamic, early-stage biotech environment.
Read More About Us
· Our Story: https://psithera.com/company/
· Team: https://psithera.com/company/team-and-leadership/
Benefits:
Competitive salary and benefits package including 401k match